Microcrystalline cellulose

Microcrystalline Cellulose (MCC)
DFE Pharma provides continuous support for your challenge to develop and produce robust and cost-effective formulations fast and successfully. By incorporating Microcrystalline Cellulose (MCC) products in our portfolio, we have increased the power of our product offering and offer our customers a wider range of support. We care for your challenges, now and in the future. DFE Pharma offers our MCC-based product Pharmacel® with the same high and consistent quality that you can expect from your global leader in pharmaceutical excipients.

Microcrystalline Cellulose

Microcrystalline Cellulose is a purified, partly depolymerised cellulose with shorter, crystalline polymer chains. Its strong binding performance make MCC one of the most commonly used fillers and binders in drug formulations, together with Lactose. The product is manufactured by controlled partial hydrolysis of high purity wood pulp, followed by purification and drying.

For formulation development, Pharmacel® can be applied in a wide variety of oral solid dosage forms, including tablets, capsules, sachets, pellets and others. MCC is widely used in diverse pharmaceutical processes, like wet granulation, dry granulation or direct compression. MCC grades with low moisture-content are especially useful for application with moisture sensitive APIs.
Pharmacel® has high compactability properties, meaning that strong tablets can be made at low forces. These low forces can increase life of tooling during tableting step in production, even when the proportion of active ingredient within a tablet is high. In addition, tablets containing MCC, can be made to disintegrate readily when a superdisintegrant, such as Primojel® or Primellose® of DFE Pharma, is used, thus maximizing the potential for drug bioavailability. Combined together with various directly compressible lactose (DCL) grades (granulated, anhydrous, spray dried), MCC exhibits improved functional properties which can be useful for direct compression applications.

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