Dapoxetine Hcl Raw Steroid Powder

Dapoxetine Hcl

Trade names : Kutub, Priligy, Duratia, Pentenal-30, Sustinex, Lejam, Dumax

  1. Dapoxetine Hcl Usage:

Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.

Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.

2. Dapoxetine Hcl Dosage 

Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE.

Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition.Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used

However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction.Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects

Interactions
With phosphodiesterase inhibitors (PDE5 inhibitors)
Many men that have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug-drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with dapoxetine 60 mg + tadalafil 20 mg; the other half were treated with dapoxetine 60 mg + sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that dapoxetine does not alter the pharmacokinetic of tadalafil or sildenafil.

With ethanol
Ethanol doesn’t affect the pharmacokinetics of dapoxetine when taking concurrently with dapoxetine.

3. Description:

English name: Dapoxetine hydrochloride
English Name: DAPOXETINE HCL; DL-Dapoxteine HCL; Hydrochloric acid Dapoxetine
CAS: 129938-20-1
Formula: C21H24ClNO
MW: 341.8744
Molecular Structure:

Raw Hormone Powder Male Enhancement Steroids Dapoxetine HCL Dapoxetine Hydrochloride

Melting point: 175-1790C
Boiling point: 480.5 ° C at 760 mmHg
Flash Point: 244.4 ° C
Vapor Pressure: 1.27E-09mmHg at 25 ° C

Dapoxetine hydrochloride is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements. There are over 1500 documents to prove the caused by different causes impotence premature ejaculation, knew the success rate is above 80%, and show its reliable curative effect, through the use of more than 20 million people worldwide, proved its long-term stability, the safety of 25 to 60 minutes of work function to coincide with a time needed for foreplay, knew the time adjustment in the highest drug concentration time, help both husband and wife a satisfactory sex life.
Initially, dapoxetine hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance. The tablet should be taken with water and may be taken with or without food, as absorption is not affected by food.

3. Specification:

Item
Requirement
Result
Appearance
White or almost white crystalline powder
Almost White Powder
Melting Point
175°C-185°C
181.2°C-182.8°C
Optical Rotation
+128±3 (C=1, CH3OH)
127.33
Loss on Drying
≤1.0%
0.20%
Ignition Residue
≤0.1%
0.10%
Purity
≥98.5%
99.47%

 

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