Carboxymethylcellulose sodium ,CMC-Na

Carboxymethylcellulose sodium ,CMC-Na

 

CMC is used in food under the E number E466 as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream. It is also a constituent of many non-food products, such as toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing, and various paper products. It is used primarily because it has high viscosity, is nontoxic, and is generally considered to be hypoallergenic as the major source fiber is either softwood pulp or cotton linter

However, “non-toxic” does not imply that CMC is good for long-term health (see Health and Safety, below). CMC is used extensively in gluten free and reduced fat food products In laundry detergents, it is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution. CMC is used as a lubricant in artificial tears.

Following the initial reaction, the resultant mixture produces about 60% CMC plus 40% salts (sodium chloride and sodium glycolate). This product is the so-called technical CMC which is used in detergents. A further purification process is used to remove these salts to produce the pure CMC used for food, pharmaceutical, and dentifrice (toothpaste) applications. An intermediate “semipurified” grade is also produced, typically used in paper applications such as restoration of archival documents.

CMC is also used in pharmaceuticals as a thickening agent, and in the oil-drilling industry as an ingredient of drilling mud, where it acts as a viscosity modifier and water retention agent.

Knitted fabric made of cellulose (eg cotton or viscose rayon) may be converted into CMC and used in various medical applications. 1 Device for epitaxis (nose bleeding). A pvc balloon is covered by CMC knitted fabric reinforced by nylon. The device is soaked in water to form a gel, this is inserted into the nose and the balloon inflated. The combination of the inflated balloon and the therapeutic effect of the cmc stops the bleeding. (see “Rapid Rhino”) 2 Fabric used as a dressing following ENT surgical procedures. 3 Added water to form a gel. This gel is inserted into sinus cavity following surgery.

Insoluble microgranular CMC is used as a cation-exchange resin in ion-exchange chromatography for purification of proteins.Presumably, the level of derivatization is much lower, so the solubility properties of microgranular cellulose are retained, while adding sufficient negatively charged carboxylate groups to bind to positively charged proteins.

CMC is also used in ice packs to form a eutectic mixture resulting in a lower freezing point, and therefore more cooling capacity than ice.

Aqueous solutions of CMC have also been used to disperse carbon nanotubes. The long CMC molecules are thought to wrap around the nanotubes, allowing them to be dispersed in water. In conservation-restoration, it is used as an adhesive or fixative (commercial name Klucel).

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